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Nov 30, 2012· Interestingly, D5 of CHR2 and the membrane-proximal FnIII domains (D6-D7) are well defined and assume the same angle, suggesting that they behave as a rigid body (Figure 2A).However, the orientation of the D5-D7 module in respect to the central ‘V’ is highly variable and assumes a continuum of angles with a range of ~40° in the plane of the carbon support of the EM grid.

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Here, we performed single-cell RNA sequencing (scRNA-seq), B cell and T cell receptor (BCR and TCR, respectively) profiling, and immune phenotyping of the colonic mucosae of a cohort of Chinese children with colitis and IBD, after which we associated candidate risk genes (which we had identified via a genome-wide association study) with subpopulations of immune and non-immune cells.

Roelofs BA, Ge SX, Studlack PE, Polster BM. Low micromolar concentrations of the superoxide probe MitoSOX uncouple neural mitochondria and inhibit complex IV. Free Radic Biol Med. 2015; 86:250–8. doi: 10.1016/j.freeradbiomed.2015.05.032. [PMC free article] [Google Scholar]

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OBJECTIVE To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes. RESEARCH DESIGN AND METHODS In this randomized, controlled, multicenter study, 120 children and adults on intensive therapy for type 1 diabetes and a screening level of glycated hemoglobin A1c (HbA1c) <7.5% were randomly assigned to a control group performing conventional home ...

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Class 125 • Bolted Cap • Bronze Trim • Flanged Ends • Lever & Weight (Figure 383) Class 125 • Bolted Cap • All Iron • Flanged Ends (Figure 373 ½) Class 250 • Bolted Cap • Bronze Trim • Flanged Ends (Figure 39E) Class 300 • Threaded Cap • Y-Pattern • All Iron • Threaded Ends (Figure 346 ½)

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Nov 21, 2019· The time courses of the plasma concentrations were almost superimposable (Figure 1). Desitrend 1000 mg coated granules in sachet were bioequivalent with the film-coated reference tablets with regard to the maximum exposure (C max ) and total exposure (AUC) to Levetiracetam: the 90% confidence intervals of the ratios for test to reference were ...

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Objective Non-alcoholic fatty liver disease (NAFLD) is a common prelude to cirrhosis and hepatocellular carcinoma. The genetic rs641738 C> T variant in the lysophosphatidylinositol acyltransferase 1 ( LPIAT1)/membrane bound O-acyltransferase domain-containing 7 , which incorporates arachidonic acid into phosphatidylinositol (PI), is associated with the entire spectrum of NAFLD.

We therefore transferred cell-type labels from the SMART-seq2 dataset to the STARmap cells, classifying 1,915 (79%) of cells with prediction score >0.5, but conservatively chose to consider the 1,210 (50%) cells with the highest prediction scores for downstream analysis (Figure 5F; STAR Methods).

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